Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC029
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-16 10:47
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment TBL madopar 3x1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 38 individuals with a value less than 0.7 were subsequently diagnosed with PD. That is, 90.48% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.7 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 2, 'TN': 2, 'TP': 40, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 3, 'TN': 4, 'TP': 39, 'FP': 26}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 13, 'TN': 8, 'TP': 29, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 4, 'TP': 37, 'FP': 26}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 6.296
timePerCircleCoV 0.14633
timePerCircleSlope -0.0361172
meanError 1.78694
tremorFreq 7.03125
tremorRelPower 29.704
tremorGyroAmpMean 0.0330009
tremorGyroAmpSlope -0.00174605
tremorGyroAmpCoV 0.429491
tremorCoordAmpMean 0.0722708
tremorCoordAmpSlope 0.00445896
tremorCoordAmpCoV 0.341239
tremorAccAmpMean 0.0572543
tremorAccAmpSlope 0.00079917
tremorAccAmpCoV 0.375583
tremorPcRelVar 0.790132
tremorPcX 0.738733
tremorPcY -0.673998

Circle Segment 1

Duration 7.08 s, Accuracy Estimate 2.228 (lower is better)

Circle Segment 2

Duration 8.48 s, Accuracy Estimate 1.715 (lower is better)

Circle Segment 3

Duration 6.04 s, Accuracy Estimate 1.992 (lower is better)

Circle Segment 4

Duration 6.08 s, Accuracy Estimate 1.906 (lower is better)

Circle Segment 5

Duration 6.16 s, Accuracy Estimate 1.855 (lower is better)

Circle Segment 6

Duration 6.52 s, Accuracy Estimate 1.122 (lower is better)

Circle Segment 7

Duration 5.72 s, Accuracy Estimate 1.462 (lower is better)

Circle Segment 8

Duration 5.96 s, Accuracy Estimate 1.58 (lower is better)

Circle Segment 9

Duration 5.8 s, Accuracy Estimate 1.44 (lower is better)

Circle Segment 10

Duration 5.12 s, Accuracy Estimate 2.571 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 14.776
timePerSpiralCoV 0.162477
timePerSpiralSlope -0.0320914
meanError 2.20984
tremorFreq 7.22656
tremorRelPower 31.1902
tremorGyroAmpMean 0.0400607
tremorGyroAmpSlope 0.00218834
tremorGyroAmpCoV 0.343463
tremorCoordAmpMean 0.101815
tremorCoordAmpSlope 0.00352278
tremorCoordAmpCoV 0.326149
tremorAccAmpMean 0.0801066
tremorAccAmpSlope 0.00344148
tremorAccAmpCoV 0.352324
tremorPcRelVar 0.783619
tremorPcX -0.679595
tremorPcY 0.733588

Spiral Segment 1

Duration 20.8 s, Accuracy Estimate 1.865 (lower is better)

Spiral Segment 2

Duration 15.24 s, Accuracy Estimate 1.966 (lower is better)

Spiral Segment 3

Duration 16.52 s, Accuracy Estimate 2.114 (lower is better)

Spiral Segment 4

Duration 13.4 s, Accuracy Estimate 2.75 (lower is better)

Spiral Segment 5

Duration 13.0 s, Accuracy Estimate 2.4 (lower is better)

Spiral Segment 6

Duration 12.52 s, Accuracy Estimate 2.105 (lower is better)

Spiral Segment 7

Duration 13.76 s, Accuracy Estimate 2.254 (lower is better)

Spiral Segment 8

Duration 14.28 s, Accuracy Estimate 2.129 (lower is better)

Spiral Segment 9

Duration 13.96 s, Accuracy Estimate 2.167 (lower is better)

Spiral Segment 10

Duration 14.28 s, Accuracy Estimate 2.348 (lower is better)

Elel

eDurationMean 0.388158
eDurationStd 0.0700812
eDurationStdnorm 0.180548
eDurationMedian 0.375
eDurationQuartdelta 0.075
eDurationQuartdeltanorm 0.2
eDurationKurt 4.66254
eDurationTrenddiff -0.065
eDurationTrendratio 0.843373
eWidthMean 6.67208
eWidthStd 1.75837
eWidthStdnorm 0.263541
eWidthMedian 6.3765
eWidthQuartdelta 2.223
eWidthQuartdeltanorm 0.348624
eWidthKurt 5.99415
eWidthTrenddiff -1.404
eWidthTrendratio 0.806452
eHeightMean 11.9894
eHeightStd 1.61863
eHeightStdnorm 0.135005
eHeightMedian 11.8755
eHeightQuartdelta 2.223
eHeightQuartdeltanorm 0.187192
eHeightKurt 3.16903
eHeightTrenddiff -1.638
eHeightTrendratio 0.87037
eAspectMean 0.552466
eAspectStd 0.0942149
eAspectStdnorm 0.170535
eAspectMedian 0.549725
eAspectQuartdelta 0.155556
eAspectQuartdeltanorm 0.28297
eAspectKurt 3.02271
eAspectTrenddiff -0.0680517
eAspectTrendratio 0.883653
eSlantMean 0.297915
eSlantStd 0.098471
eSlantStdnorm 0.330534
eSlantMedian 0.307516
eSlantQuartdelta 0.140741
eSlantQuartdeltanorm 0.457669
eSlantKurt 3.57417
eSlantTrenddiff -0.0237255
eRtopMean 0.873824
eRtopStd 0.0652983
eRtopStdnorm 0.074727
eRtopMedian 0.885931
eRtopQuartdelta 0.093913
eRtopQuartdeltanorm 0.106005
eRtopKurt 3.45201
eRtopTrenddiff 0.018617
eRbotMean 0.340525
eRbotStd 0.0917615
eRbotStdnorm 0.26947
eRbotMedian 0.345058
eRbotQuartdelta 0.130499
eRbotQuartdeltanorm 0.378193
eRbotKurt 2.98344
eRbotTrenddiff 0.00829726
eRrightMean 0.926315
eRrightStd 0.0649423
eRrightStdnorm 0.0701082
eRrightMedian 0.944132
eRrightQuartdelta 0.0508751
eRrightQuartdeltanorm 0.0538855
eRrightKurt 17.6006
eRrightTrenddiff -0.00062422
eRleftMean 0.199029
eRleftStd 0.0663724
eRleftStdnorm 0.333481
eRleftMedian 0.195048
eRleftQuartdelta 0.0651648
eRleftQuartdeltanorm 0.334096
eRleftKurt 3.92233
eRleftTrenddiff -0.0101541
lDurationMean 0.573625
lDurationStd 0.142456
lDurationStdnorm 0.248343
lDurationMedian 0.5675
lDurationQuartdelta 0.1675
lDurationQuartdeltanorm 0.295154
lDurationKurt 6.47526
lDurationTrenddiff -0.155
lDurationTrendratio 0.751004
lWidthMean 14.4261
lWidthStd 2.09148
lWidthStdnorm 0.144979
lWidthMedian 14.157
lWidthQuartdelta 3.2175
lWidthQuartdeltanorm 0.227273
lWidthKurt 2.54552
lWidthTrenddiff 0.468
lWidthTrendratio 1.03361
lHeightMean 26.9568
lHeightStd 3.20459
lHeightStdnorm 0.118879
lHeightMedian 26.1495
lHeightQuartdelta 3.6855
lHeightQuartdeltanorm 0.14094
lHeightKurt 3.65582
lHeightTrenddiff -0.2925
lHeightTrendratio 0.988938
lAspectMean 0.538892
lAspectStd 0.0783312
lAspectStdnorm 0.145356
lAspectMedian 0.535887
lAspectQuartdelta 0.116103
lAspectQuartdeltanorm 0.216656
lAspectKurt 2.28955
lAspectTrenddiff 0.0682841
lAspectTrendratio 1.13596
lSlantMean 0.369569
lSlantStd 0.0951791
lSlantStdnorm 0.257541
lSlantMedian 0.355991
lSlantQuartdelta 0.157041
lSlantQuartdeltanorm 0.441138
lSlantKurt 2.38937
lSlantTrenddiff 0.12177
lRtopMean 0.918882
lRtopStd 0.041805
lRtopStdnorm 0.0454955
lRtopMedian 0.920499
lRtopQuartdelta 0.0488646
lRtopQuartdeltanorm 0.053085
lRtopKurt 3.10124
lRtopTrenddiff 0.0281305
lRbotMean 0.240909
lRbotStd 0.0820444
lRbotStdnorm 0.340562
lRbotMedian 0.232162
lRbotQuartdelta 0.115255
lRbotQuartdeltanorm 0.496441
lRbotKurt 2.30819
lRbotTrenddiff -0.0942414
lRrightMean 0.944174
lRrightStd 0.0343682
lRrightStdnorm 0.0364003
lRrightMedian 0.947115
lRrightQuartdelta 0.0452865
lRrightQuartdeltanorm 0.0478151
lRrightKurt 2.4186
lRrightTrenddiff 0.0305365
lRleftMean 0.120978
lRleftStd 0.0423346
lRleftStdnorm 0.349937
lRleftMedian 0.113177
lRleftQuartdelta 0.0366812
lRleftQuartdeltanorm 0.324104
lRleftKurt 3.99136
lRleftTrenddiff -0.00324513

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.900304
sumTouchScores 25.2085
meanMovementTime 0.632593
numTouches 28
undershootPercentage 0
overshootPercentage 21.4286

FITTS Long Modified

meanTouchScore 0.917352
sumTouchScores 16.5123
meanMovementTime 1.01588
numTouches 18
undershootPercentage 5.55556
overshootPercentage 16.6667

ZigZag

numZigzags 5
timePerZigzagMean 15.936
timePerZigzagCoV 0.173924
timePerZigzagSlope 0.0554719
meanError 2.23063
tremorFreq 7.22656
tremorRelPower 26.1826
tremorGyroAmpMean 0.0763869
tremorGyroAmpSlope -0.0117841
tremorGyroAmpCoV 0.445336
tremorCoordAmpMean 0.163475
tremorCoordAmpSlope -0.00681577
tremorCoordAmpCoV 0.426315
tremorAccAmpMean 0.142118
tremorAccAmpSlope -0.00726541
tremorAccAmpCoV 0.430784
tremorPcRelVar 0.848982
tremorPcX 0.385448
tremorPcY 0.92273

ZigZag Segment 1

Duration 14.48 s, Accuracy Estimate 2.375 (lower is better)

ZigZag Segment 2

Duration 12.52 s, Accuracy Estimate 2.769 (lower is better)

ZigZag Segment 3

Duration 19.76 s, Accuracy Estimate 1.733 (lower is better)

ZigZag Segment 4

Duration 15.52 s, Accuracy Estimate 1.96 (lower is better)

ZigZag Segment 5

Duration 17.4 s, Accuracy Estimate 2.316 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 10.832
timePerZigzagCoV 0.0985144
timePerZigzagSlope -0.0531758
zigzagHeightMean 64.4909
zigzagHeightCoV 0.0279672
zigzagHeightSlope -0.0138647
meanError 0.0370559
tremorFreq 6.73828
tremorRelPower 37.5125
tremorGyroAmpMean 0.129528
tremorGyroAmpSlope -0.00230833
tremorGyroAmpCoV 0.275208
tremorCoordAmpMean 0.222351
tremorCoordAmpSlope 0.00130261
tremorCoordAmpCoV 0.341577
tremorAccAmpMean 0.187542
tremorAccAmpSlope 0.00120606
tremorAccAmpCoV 0.343969
tremorPcRelVar 0.875673
tremorPcX 0.316154
tremorPcY 0.948708

ZigZag Offset Segment 1

Duration 12.52 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 2

Duration 10.56 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 3

Duration 10.8 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 4

Duration 10.72 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 5

Duration 9.56 s, Accuracy Estimate 0.067 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.78}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.7}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.5243014468702152}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.29725674018738757}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.3446445594469443}